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Acyclovir tolerance in humans.

R E Keeney, L E Kirk, D Bridgen

The American Journal of Medicine

|July 20, 1982

Summary

This summary is machine-generated.

Acyclovir is a safe and effective antiherpes agent. Clinical studies across diverse populations and formulations confirm its favorable safety profile, making it the leading choice for herpes treatment.

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Area of Science:

Pharmacology
Virology
Clinical Trials

Background:

Acyclovir is an antiviral medication used to treat herpes infections.
Assessing the safety and tolerance of acyclovir is crucial for its widespread clinical application.

Purpose of the Study:

To evaluate the safety and tolerance of acyclovir in various human populations and dosage regimens.
To compare acyclovir's safety profile against potential toxicities in vulnerable patient groups.

Main Methods:

Phase I pharmacokinetic and tolerance studies in special populations.
Phase II placebo-controlled studies in patients with herpes infections.
Evaluation of intravenous, topical, and oral acyclovir formulations.

Main Results:

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Acyclovir demonstrated a favorable safety profile across all tested formulations and populations.
Studies in special populations confirmed safety, even in patients at risk for drug toxicity.
Phase II studies further supported the safety of acyclovir in infected patients.

Conclusions:

Acyclovir is confirmed as the safest antiherpes agent studied to date.
The established safety of acyclovir supports its use in treating herpes infections.
Continued research reinforces acyclovir's position as a leading antiviral therapy.