Cefotaxime ("Claforan') in routine hospital use

Area of Science:

• Infectious Diseases
• Pharmacology

Background:

• Moderate to severe infections pose significant clinical challenges.
• Effective antibiotic therapy is crucial for patient outcomes.

Purpose of the Study:

• To evaluate the efficacy and safety of cefotaxime in treating diverse moderate to severe infections.
• To determine bacteriological eradication and clinical success rates.

Main Methods:

• A multi-centre study involving 327 patients.
• Treatment with cefotaxime at recommended dosages, often as monotherapy.
• Assessment of bacteriological eradication and clinical response.

Main Results:

• Bacteriological eradication rate of 83%.
• Clinical success rate of 92% in assessable cases.
• Low incidence of adverse events (3% relapse, 5% failure).

Conclusions:

• Cefotaxime demonstrates high efficacy and a favorable safety profile.
• It is a suitable treatment option for moderate to severe infections.