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Herpesvirus saimiri strain variability.

R C Desrosiers, L A Falk

    Journal of Virology
    |July 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    Herpesvirus saimiri strains show significant variability in squirrel monkeys, with most isolates being distinguishable. This herpesvirus exhibits greater genetic diversity than previously observed in related viruses.

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    Area of Science:

    • Virology
    • Primate Virology
    • Molecular Biology

    Background:

    • Herpesvirus saimiri is a significant pathogen in non-human primates.
    • Understanding the genetic diversity of viral strains is crucial for epidemiological studies and vaccine development.

    Purpose of the Study:

    • To investigate the genetic variability of Herpesvirus saimiri strains isolated from squirrel monkeys.
    • To assess the potential for geographic or temporal strain differentiation.

    Main Methods:

    • Isolation of Herpesvirus saimiri from squirrel monkey peripheral lymphocytes via cocultivation.
    • Analysis of viral strain variability using restriction endonuclease digestion of virion DNA fragments.

    Main Results:

    • Nineteen out of 22 Herpesvirus saimiri isolates were distinguishable based on DNA fragment patterns.

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  • No distinct subtypes were identified specific to geographic regions of origin.
  • Colony-born squirrel monkeys yielded strains different from their mothers.
  • Viral strains isolated from the same animals over time showed significant variability.

    • Conclusions:

    • Herpesvirus saimiri exhibits a high degree of genetic variability among strains, exceeding that of other known herpesviruses.
    • The observed variability suggests rapid evolution or complex transmission dynamics within squirrel monkey populations.
    • Further research is needed to understand the implications of this genetic diversity for disease pathogenesis and control.