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Monitoring the Cancer-Immunity Cycle and Exploring Tumor Microenvironment Dynamics

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Published on: June 7, 2024

Mental neuropathy from systemic cancer.

E W Massey, J Moore, S C Schold

|October 1, 1981

Summary

A numb chin can be an early sign of cancer, particularly in patients with lymphoreticular or solid tumors. While cancer treatment can improve neuropathy, the prognosis remains poor, highlighting the need for prompt cancer screening.

Area of Science:

Neurology
Oncology

Background:

Mental neuropathy, characterized by numbness in the chin, can be an early indicator of underlying systemic cancer.
This symptom is often associated with various malignancies, including lymphoreticular and solid tumors.

Observation:

Nineteen patients with cancer-related mental neuropathy were studied.
In nine patients, the numb chin was the initial presenting symptom of their neoplasm.
Mandibular radiograms were abnormal in 5 of 12 patients, and cerebrospinal fluid analysis revealed malignant cells in two.

Findings:

Sixteen of the 19 patients experienced complete or partial resolution of neuropathy with radiation or chemotherapy.
Eight patients achieved resolution with chemotherapy alone.
Despite treatment, 16 patients died within 17 months of neuropathy onset.

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Implications:

A nontraumatic mental neuropathy warrants an immediate and thorough search for occult cancer.
Early detection and treatment of cancer may improve neuropathy symptoms but do not significantly alter the overall poor prognosis.
This study underscores the importance of considering neurological symptoms as potential indicators of advanced malignancy.