[Comparative study of ceftriaxone, cefotaxime and moxalactam against 150 Gram negative strains (author's transl)]

The in vitro activity of ceftriaxone, a new cephalosporine derivative was compared with two other "third generation" cephalosporins, cefotaxime and moxalactam. 150 strains of Gram negative bacilli were used in this study. Ceftriaxone as cefotaxime and moxalactam were very active against most of the 104 multiresistant Enterobacteriaceae. Ceftriaxone was the most active against Proteus providencia with a mean MIC of 0.007 microgram/ml. Cefotaxime and ceftriaxone were less active than moxalactam against Enterobacter with MIC higher or equal to 32 micrograms/ml. The three cephalosporins had an almost identical activity against carbenicillin resistant Pseudomonas with an MIC higher than 4 micrograms/ml. MIC against Acinetobacter were higher or equal to 16 micrograms/ml. Moxalactam was the most active against Bacteroides fragilis with a mean MIC of 0.5 micrograms/ml; ceftriaxone and cefotaxime had a mean MIC of 2 to 4 micrograms/ml.