Adrenoleukodystrophy. A correlative analysis of computed tomography and radionuclide studies

A discrepancy in location of abnormality has been noted between computed tomography (CT) and radionuclide studies in patients with adrenoleukodystrophy (ALD). Radionuclide concentration occurs only in the periphery of the lesion or area of acute demyelinating process and no concentration is seen in the area af gliosis whereas gliosis appears as a low-density lesion in the CT scan. Forward migration of radionuclide uptake in the follow-up study is another characteristic feature of this disease.