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Recurrent and metastatic cystosarcoma phyllodes.

K D Lindquist, J A van Heerden, L H Weiland

    American Journal of Surgery
    |September 1, 1982
    PubMed
    Summary
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    Cystosarcoma phyllodes can recur, with malignant potential unpredictable by standard histology. Simple mastectomy is the recommended treatment for this rare breast tumor.

    Area of Science:

    • Oncology
    • Pathology
    • Surgical Oncology

    Background:

    • Cystosarcoma phyllodes is a rare breast tumor with unpredictable malignant potential.
    • Understanding recurrence and metastasis patterns is crucial for patient outcomes.

    Purpose of the Study:

    • To analyze the clinical course and outcomes of patients with cystosarcoma phyllodes.
    • To identify predictors of malignant or metastatic potential.
    • To determine the optimal surgical approach.

    Main Methods:

    • Retrospective review of 42 patients diagnosed with cystosarcoma phyllodes between 1950 and 1980 at the Mayo Clinic.
    • Histological evaluation of tumor contour, stromal atypia, and mitotic activity.
    • Analysis of recurrence, metastasis, and survival rates.

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    Main Results:

    • Ten patients (24%) experienced recurrence or metastasis.
    • Histological features did not reliably predict malignant or metastatic potential.
    • Metastasis occurred primarily via hematogenous spread.
    • No patient with metastasis survived; 50% of metastatic cases were fatal within 2-7 years.

    Conclusions:

    • Malignant potential of cystosarcoma phyllodes is difficult to predict histologically.
    • Hematogenous spread is the main route of metastasis, with poor prognosis.
    • Simple mastectomy is the preferred surgical treatment for cystosarcoma phyllodes.