Change in plasma cAMP and catecholamines in men subjected to the same relative amount of physical work stress

This study has shown, for the first time, that the change in plasma adenosine 3',5' cyclic monophosphate (cAMP), from accommodation or trough levels, correlates highly in both progressive and continuous work stress experiments with epinephrine (E) at 0.990 and 0.898, and norepinephrine (NE) at 0.954 and 0.927, respectively, in men subjected to the same relative, rather than absolute, stress levels. All three analytes increased significantly (p less than 0.05) by the time each subject had reached 80% of their Vo2 max in the progressive experiments and after working at 80% of their Vo2 max continuously for 10 min. In no case did plasma cAMP rise before the catecholamines. The possible significance of these observations to net perceived relative physiological stress are discussed.