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Plasma citrate during submaximal and intermittent supramaximal exercise.

Scandinavian Journal of Clinical and Laboratory Investigation

|February 1, 1978

Summary

Plasma citrate levels decrease during prolonged submaximal exercise but increase after intense intermittent exercise. These changes correlate with free fatty acids and lactate, suggesting a role in muscle energy metabolism.

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Area of Science:

Exercise Physiology
Biochemistry

Background:

Citrate plays a key regulatory role in glucose oxidation within muscle cells.
Understanding plasma citrate dynamics during exercise is crucial for metabolic insights.

Purpose of the Study:

To investigate the changes in plasma citrate concentrations during and after submaximal and supramaximal exercise.
To explore the relationship between plasma citrate and other key metabolites like lactate, glucose, and free fatty acids during different exercise intensities.

Main Methods:

Measured plasma citrate, lactate, glucose, and free fatty acids in subjects undergoing 45 minutes of submaximal exercise (50-60% maximal aerobic power).
Assessed these metabolites in subjects performing intermittent supramaximal exercise (five 1-minute bursts).
Analyzed plasma concentrations at rest, during exercise, and during recovery periods.

Main Results:

During submaximal exercise, plasma citrate decreased initially then increased significantly above resting levels during recovery.
Intermittent supramaximal exercise led to a marked increase in plasma citrate during and after the exercise bouts.
Plasma citrate showed positive correlations with free fatty acids and inverse correlations with lactate during submaximal exercise, with opposite trends during supramaximal exercise.

Conclusions:

Plasma citrate levels respond dynamically to different exercise intensities and recovery patterns.
The observed variations in plasma citrate suggest its involvement in regulating muscle energy metabolism, potentially mirroring cytosolic citrate changes.
Citrate's metabolic role appears to differ between sustained submaximal and high-intensity intermittent exercise.

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