Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Bone phosphorus/hydroxyproline ratio and bone histomorphometry in normals.

L Tougaard, F Melsen, L Mosekilde

    Scandinavian Journal of Clinical and Laboratory Investigation
    |February 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Double lamellae in trabecular osteons: towards a new method for age estimation by bone microscopy.

    Homo : internationale Zeitschrift fur die vergleichende Forschung am Menschen·2007
    Same author

    Plasma 25-hydroxyvitamin D and not 1,25-dihydroxyvitamin D is associated with parathyroid adenoma secretion in primary hyperparathyroidism: a cross-sectional study.

    European journal of endocrinology·2006
    Same author

    Vitamin D status, seasonal variations, parathyroid adenoma weight and bone mineral density in primary hyperparathyroidism.

    Clinical endocrinology·2005
    Same author

    MR imaging of the normal sacroiliac joint with correlation to histology.

    Skeletal radiology·2003
    Same author

    Effects of long-term risedronate on bone quality and bone turnover in women with postmenopausal osteoporosis.

    Bone·2002
    Same author

    Cancellous bone remodeling occurs in specialized compartments lined by cells expressing osteoblastic markers.

    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research·2001
    Same journal

    When hemolysis changes interpretation: decision-level shifts and reportability failures in routine coagulation testing.

    Scandinavian journal of clinical and laboratory investigation·2026
    Same journal

    Vitamin K-dependent proteins in patients undergoing head and neck free flap surgery - a prospective observational study.

    Scandinavian journal of clinical and laboratory investigation·2026
    Same journal

    Challenges in the interpretation of amphetamine results: differences of reactivity between immunoassay and immunochromatography.

    Scandinavian journal of clinical and laboratory investigation·2026
    Same journal

    Maternal whole blood mercury, cadmium and lead concentrations during pregnancy and lactation and infant heavy metal status at six months.

    Scandinavian journal of clinical and laboratory investigation·2026
    Same journal

    Performance of Sysmex SP-50 automated slidemakers and stainers in three hematology laboratories.

    Scandinavian journal of clinical and laboratory investigation·2026
    Same journal

    Digital misinformation and parental resistance to newborn heel-prick screening: an Instagram content analysis.

    Scandinavian journal of clinical and laboratory investigation·2026
    See all related articles

    The bone phosphorus/hydroxyproline (P/Hypro) ratio offers a reliable biochemical marker for assessing bone mineralization and osteoid formation in healthy individuals. This ratio significantly correlates with key histomorphometric parameters of bone tissue.

    Area of Science:

    • Biochemistry
    • Orthopedics
    • Bone Biology

    Background:

    • Bone histomorphometry is a standard method for evaluating bone tissue characteristics.
    • Biochemical markers offer a less invasive alternative for assessing bone metabolism.
    • The phosphorus/hydroxyproline (P/Hypro) ratio is a potential biochemical indicator of bone matrix composition.

    Purpose of the Study:

    • To compare the bone phosphorus/hydroxyproline (P/Hypro) ratio with traditional bone histomorphometry.
    • To determine the correlation between the P/Hypro ratio and mineralized bone volume, osteoid volume, and osteoid surface in trabecular bone.

    Main Methods:

    • Analysis of bone samples from thirty-four normal individuals.
    • Measurement of bone phosphorus and hydroxyproline content.

    Related Experiment Videos

  • Comparison of the P/Hypro ratio with standard bone histomorphometry techniques.

    • Main Results:

    • A significant positive correlation was found between the bone P/Hypro ratio and relative mineralized bone volume (r = 0.38, P < 0.05).
    • A significant negative correlation was observed between the bone P/Hypro ratio and relative osteoid volume (r = -0.38, P < 0.05).
    • The bone P/Hypro ratio also showed a significant negative correlation with the percentage of osteoid-covered surfaces in trabecular bone (r = -0.38, P < 0.05).

    Conclusions:

    • The bone P/Hypro ratio serves as a valid biochemical marker reflecting bone mineralization status.
    • This ratio correlates significantly with key histomorphometric parameters, indicating its utility in assessing bone tissue characteristics.
    • The findings suggest the P/Hypro ratio can provide insights into bone formation and remodeling processes.