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Concomitant decrease in [3H]imipramine binding in cat brain and platelets after chronic treatment with imipramine.

M Briley, R Raisman, S Arbilla

    European Journal of Pharmacology
    |July 9, 1982
    PubMed
    Summary
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    Chronic imipramine treatment in cats reduced [3H]imipramine binding in the brain and platelets. This finding parallels reduced binding in platelets of depressed patients, suggesting imipramine

    Area of Science:

    • Neuroscience
    • Pharmacology
    • Biochemistry

    Background:

    • Imipramine is a widely used antidepressant.
    • Its mechanism of action involves neurotransmitter reuptake inhibition.
    • Platelets are often used as a model for studying brain receptor changes.

    Purpose of the Study:

    • To investigate the effects of chronic imipramine administration on specific neurotransmitter receptor binding in the feline brain and platelets.
    • To compare these changes with findings in human depression.

    Main Methods:

    • Cats were administered imipramine (7.5 mg/kg) twice daily for 20 days.
    • Maximal binding of [3H]dihydroalprenolol and [3H]spiroperidol was measured in the cerebral cortex.
    • Maximal binding of [3H]imipramine was assessed in both the hypothalamus and platelets.

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    Main Results:

    • Chronic imipramine treatment significantly reduced maximal [3H]dihydroalprenolol binding in the cerebral cortex.
    • [3H]Spiperidol binding to 5HT2-receptors in the cortex remained unchanged.
    • A parallel decrease in maximal [3H]imipramine binding was observed in both the hypothalamus and platelets.

    Conclusions:

    • Chronic imipramine treatment downregulates beta-adrenergic receptors in the feline cerebral cortex.
    • The parallel reduction in [3H]imipramine binding in brain and platelets suggests platelets may serve as a useful peripheral marker for imipramine binding changes in the brain.
    • These findings support the potential utility of platelet [3H]imipramine binding as a biomarker in depression research.