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Related Experiment Videos

Age-dependent decrease of alpha 2-adrenergic receptor number in human platelets.

O E Brodde, M Anlauf, N Graben

    European Journal of Pharmacology
    |July 9, 1982
    PubMed
    Summary
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    As people age, the number of alpha 2-adrenergic receptors decreases, while plasma catecholamines increase. This reduction in receptors may explain diminished adrenergic responses in older adults.

    Area of Science:

    • Pharmacology
    • Gerontology
    • Cardiovascular Physiology

    Background:

    • Adrenergic receptors play a crucial role in regulating physiological responses to stress and stimuli.
    • Age-related changes in receptor density and function are well-documented but not fully understood.
    • Platelet alpha 2-adrenergic receptors are accessible markers for studying adrenergic system changes.

    Purpose of the Study:

    • To investigate the relationship between age and the number of platelet alpha 2-adrenergic receptors.
    • To examine the correlation between age and plasma catecholamine levels.
    • To elucidate potential mechanisms for reduced adrenergic responsiveness in the elderly.

    Main Methods:

    • Quantified alpha 2-adrenergic receptors using [3H]yohimbine binding in platelets from 36 healthy subjects (aged 14-76).

    Related Experiment Videos

  • Measured plasma catecholamine concentrations in the same cohort.
  • Analyzed correlations between receptor number, plasma catecholamines, and age.

    • Main Results:

    • A significant negative correlation was observed between alpha 2-adrenergic receptor density and age (r = -0.666, P < 0.001).
    • Plasma catecholamine concentrations showed a significant positive correlation with increasing age.
    • These findings indicate an inverse relationship between receptor availability and chronological aging.

    Conclusions:

    • Reduced alpha 2-adrenergic receptor numbers in platelets are associated with aging.
    • Elevated plasma catecholamines with age may reflect compensatory mechanisms or altered regulation.
    • The decline in alpha 2-adrenergic receptors likely contributes to the diminished physiological responses to adrenergic stimuli observed in older individuals.