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Nonhistone proteins HMG1 and HMG2 change the DNA helical structure
Science (New York, N.Y.)
|March 24, 1978
Abstract:
Two chromatin nonhistone proteins (from calf thymus) of the high mobility group, HMG1 and HMG2, reduce the linking number (topological winding number) of a circular DNA if the covalent closure of the DNA is carried out in their presence. This indicates that these proteins can either unwind the double helix, or induce a supercoiling of the DNA.