Pharmacokinetics of ceftizoxime in patients undergoing hemodialysis

Serum pharmacokinetics of 1 g ceftizoxime were studied in eight patients undergoing chronic haemodialysis. Arterial blood samples were collected at 3, 60, 120, 180 and 240 minutes and before the next dialysis 2-3 days after injection of ceftizoxime. Three minutes after injection the serum levels were 122 +/- 8.4 microgram/ml and 19.4 +/- 1.7 microgram/ml at the end of the dialysis. Mean elimination half-life under haemodialysis was 2.1 hours. Serum concentrations ranged from 4.9 to 13 microgram/ml two to three days after the haemodialysis.