Animal studies on the efficacy of vaccination against recurrent herpes

Guinea pigs, latently infected with herpes simplex virus type 2 (HSV 2), were immunized with an HSV 2 vaccine derived from extracts of infected cells and either formol inactivated or detergent treated. Although such postinfection vaccination could significantly increase the titers of neutralizing antibodies, it had no effect on the course of recurrent herpes in these animals.