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Updated: Aug 16, 2026

Induction and Assessment of Class Switch Recombination in Purified Murine B Cells
Published on: August 13, 2010
Immunoglobulin switch region-like sequences in Drosophila melanogaster
Abstract:
We found immunoglobulin switch (S) region-like sequences in DNAs of wide variety of organisms including sea urchin, yeast and Drosophila that do not produce immunoglobulins. DNA fragments carrying Smu-like sequences were cloned from Drosophila and the nucleotide sequence of a clone is almost identical to that of the mouse Smu region. Restriction fragments of Drosophila Smu-like sequences and their flanking regions seem to vary among Drosophila species. Possible evolutionary significance of the Smu-like sequence in invertebrates was discussed.
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