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Gastric acid secretion using pentagastrin: dose-response studies.

O O Adekunle, S O Osanyintuyi, O Ayeni

    African Journal of Medicine and Medical Sciences
    |September 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

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    Pentagastrin stimulation in Nigerians with duodenal ulcers showed an optimal dose of 6 micrograms/kg bodyweight. While this dose matches Caucasian recommendations, Nigerian males exhibited higher maximum acid output (MAO).

    Area of Science:

    • Gastroenterology
    • Clinical Pharmacology
    • Human Physiology

    Background:

    • Duodenal ulcer disease is a significant health concern.
    • Gastric acid secretion plays a key role in ulcer pathogenesis.
    • Understanding ethnic variations in gastric response is crucial for effective treatment.

    Purpose of the Study:

    • To determine the optimal pentagastrin dose for gastric acid stimulation in Nigerians.
    • To compare gastric acid output in Nigerian duodenal ulcer patients and controls.
    • To assess ethnic differences in gastric acid response to pentagastrin.

    Main Methods:

    • Twenty-five Nigerian participants (20 duodenal ulcer cases, 5 controls) were studied.
    • Gastric stimulation was performed using pentagastrin at doses of 4, 6, 8, and 10 micrograms/kg bodyweight.

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  • Maximum acid output (MAO) was measured and analyzed based on sex and diagnosis.

    • Main Results:

    • The optimal pentagastrin dose for maximal gastric acid response in Nigerian patients was 6 micrograms/kg bodyweight.
    • The overall MAO at the optimal dose was 15.14 mEq/hr, with males (19 mEq/hr) showing higher output than females (12.50 mEq/hr).
    • The optimal dose of 6 micrograms/kg bodyweight aligns with Caucasian studies, but MAO was notably higher in Nigerian males.

    Conclusions:

    • The optimal pentagastrin dose for gastric acid stimulation in Nigerians is 6 micrograms/kg bodyweight.
    • Nigerian males exhibit a higher maximal acid output compared to females at the optimal pentagastrin dose.
    • While the optimal pentagastrin dose is consistent across ethnic groups studied, significant sex-based differences in acid output exist within the Nigerian population.