Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Ceftriaxone: in vitro studies and clinical evaluation.

J W Gnann, W E Goetter, A M Elliott

    Antimicrobial Agents and Chemotherapy
    |July 1, 1982
    PubMed
    Summary

    Ceftriaxone demonstrates high in vitro activity against many gram-negative bacilli, proving effective in treating serious infections. Clinical trials show excellent efficacy with a 93% cure rate and good tolerability in patients.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Is birth weight associated with blood pressure among African children and adolescents? A systematic review.

    Journal of developmental origins of health and disease·2018
    Same author

    Characterization of plastic and boron carbide additive manufactured neutron collimators.

    The Review of scientific instruments·2018
    Same author

    Schistosoma mansoni-specific immune responses and allergy in Uganda.

    Parasite immunology·2017
    Same author

    Heart-hand syndrome IV: a second family with LMNA-related cardiomyopathy and brachydactyly.

    Clinical genetics·2016
    Same author

    Human eosinophils modulate peripheral blood mononuclear cell response to Schistosoma mansoni adult worm antigen in vitro.

    Parasite immunology·2016
    Same author

    Helminths are positively associated with atopy and wheeze in Ugandan fishing communities: results from a cross-sectional survey.

    Allergy·2016

    Area of Science:

    • Microbiology
    • Infectious Diseases
    • Clinical Pharmacology

    Background:

    • Gram-negative bacilli are significant causes of serious infections.
    • Ceftriaxone is a third-generation cephalosporin antibiotic.
    • Understanding ceftriaxone's spectrum of activity and clinical utility is crucial.

    Purpose of the Study:

    • To determine the in vitro activity of ceftriaxone against clinical isolates of gram-negative bacilli.
    • To evaluate the clinical efficacy and toxicity of ceftriaxone in adult patients with bacterial infections.

    Main Methods:

    • In vitro susceptibility testing of ceftriaxone against 437 gram-negative bacilli isolates.
    • Clinical trial evaluating ceftriaxone in 55 adult patients with various infections.

    Main Results:

    • Ceftriaxone exhibited high in vitro activity against Enterobacteriaceae (except Enterobacter cloacae) but minimal activity against Pseudomonas aeruginosa and Acinetobacter calcoaceticus.
    • In 30 patients with confirmed bacterial infections (including pneumonia, UTIs, soft tissue/bone infections), ceftriaxone achieved an overall clinical and bacteriological cure rate of 93%.
    • Adverse reactions occurred in 22 patients, with elevated hepatic enzymes, thrombocytosis, and eosinophilia being most frequent; only one case required treatment discontinuation.

    Conclusions:

    • Ceftriaxone is highly effective in vitro against many common gram-negative pathogens.
    • Ceftriaxone demonstrates excellent clinical efficacy and is well-tolerated for treating serious gram-negative bacillary infections.
    • Ceftriaxone shows promise as a valuable therapeutic option for severe bacterial infections.

    Related Experiment Videos