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Related Experiment Videos

Apparent ketoconazole failure in candidal cholecystitis.

B J Brooks, W L Williams, C V Sanders

    Archives of Internal Medicine
    |October 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

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    Fungal acalculous cholecystitis is a rare complication of systemic candidiasis. While ketoconazole treated the systemic infection, it did not clear the fungus from the biliary tract.

    Area of Science:

    • Medical Mycology
    • Gastroenterology
    • Infectious Diseases

    Background:

    • Disseminated candidal infections can lead to rare complications.
    • Fungal acalculous cholecystitis is an uncommon manifestation.
    • Diabetes and broad-spectrum antibiotic use are risk factors.

    Observation:

    • A case of systemic candidiasis is presented in a diabetic patient.
    • The patient received antibiotics for an infected foot ulcer.
    • Fungal infection affected the biliary tract.

    Findings:

    • Ketoconazole, an imidazole antifungal, successfully treated systemic candidiasis.
    • However, ketoconazole failed to eradicate the fungal infection in the biliary tract.
    • This highlights challenges in treating biliary fungal infections.

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    Implications:

    • Fungal acalculous cholecystitis requires specific diagnostic and treatment considerations.
    • Antifungal therapy may need to be tailored for biliary tract involvement.
    • Further research into effective treatments for fungal cholecystitis is warranted.