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Hypercalcemia and primary hepatic tumors.

W A Oldenburg, J A van Heerden, G W Sizemore

    Archives of Surgery (Chicago, Ill. : 1960)
    |October 1, 1982
    PubMed
    Summary

    Hypercalcemia, high blood calcium, is common in primary liver tumors, especially cholangiocarcinomas. Surgical removal of the liver tumor can help control hypercalcemia.

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    Area of Science:

    • Oncology
    • Endocrinology

    Background:

    • Primary liver tumors, including hepatocellular carcinoma and cholangiocarcinoma, are significant health concerns.
    • Hypercalcemia, elevated serum calcium, can be a serious complication of various malignancies.

    Observation:

    • A review of 192 patients with primary liver tumors (1969-1980) identified hypercalcemia in 5.3% with hepatocellular carcinoma and 17.5% with cholangiocarcinoma.
    • Eight patients with hepatocellular carcinoma and seven with cholangiocarcinoma presented with hypercalcemia of unknown etiology.

    Findings:

    • Five hypercalcemic patients exhibited immunoreactive parathyroid hormone levels indicative of ectopic hyperparathyroidism.
    • Another five patients met Lafferty's criteria for pseudohyperparathyroidism, characterized by high serum calcium, low phosphate, and low chloride.

    Implications:

    • Hypercalcemia is a relatively common paraneoplastic syndrome associated with primary hepatic tumors.
    • The incidence of hypercalcemia varies significantly based on the specific type of primary liver tumor.
    • Surgical resection of the primary hepatic tumor offers a potential therapeutic strategy for managing associated hypercalcemia.

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