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Related Experiment Videos

Blue collection bag after ileal diversion.

T A Hildreth, A S Cass

    Urology
    |February 1, 1978
    PubMed
    Summary

    Children with ileal diversions may experience asymptomatic blue urine due to indican, a tryptophan derivative. This harmless phenomenon causes urine to turn blue when exposed to air, resolving on its own.

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    Area of Science:

    • Pediatric Medicine
    • Biochemistry
    • Urology

    Background:

    • Ileal diversions are surgical procedures that alter the normal flow of urine.
    • Asymptomatic blue staining of urine collection bags has been observed in some pediatric patients.
    • The cause of this blue discoloration was previously unclear.

    Purpose of the Study:

    • To investigate the cause of asymptomatic blue urine in children with ileal diversions.
    • To identify the specific compound responsible for the blue staining.
    • To determine the clinical significance of this observation.

    Main Methods:

    • Clinical observation of five pediatric patients with ileal diversions.
    • Urinalysis to identify potential causative agents.
    • Biochemical analysis of urine samples.

    Main Results:

    • Asymptomatic blue staining of urine collection bags was noted in all five patients.
    • Indican, a tryptophan derivative, was identified in the urine of affected children.
    • Indican is known to oxidize to indigo blue upon exposure to air.

    Conclusions:

    • The blue staining of urine in these pediatric patients is attributed to indican.
    • This is a benign, transient phenomenon related to tryptophan metabolism and urine oxidation.
    • No adverse health effects were associated with the blue urine, suggesting it is a harmless finding.

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