Related Experiment Videos
[Urinary excretion of calcium and cyclic adenosine monophosphate in children. Comparison between the two variables]
Insights
In healthy children, urinary cyclic adenosine monophosphate (cyclic AMP) levels decrease with age. A positive correlation exists between urinary calcium and cyclic AMP, suggesting a link in pediatric renal function.
Area of Science:
- Pediatric Nephrology
- Clinical Chemistry
- Biochemical Markers
Background:
- Urinary calcium and cyclic AMP are key indicators of renal function and calcium homeostasis.
- Understanding age-related changes in these markers is crucial for pediatric health assessment.
Purpose of the Study:
- To investigate the relationship between urinary calcium and cyclic AMP excretion in healthy children.
- To determine age-specific patterns of these urinary markers in pediatric populations.
Main Methods:
- Measured urinary calcium and cyclic adenosine 3'5' monophosphate (cyclic AMP) levels in 79 healthy children aged 2-12 years.
- Expressed results as mg/g creatinine for calcium and mumol/g creatinine for cyclic AMP.
- Analyzed data for age-related trends and correlations between calcium and cyclic AMP.
Main Results:
- No significant age-related pattern was observed for urinary calcium excretion.
- Urinary cyclic AMP levels showed a significant inverse correlation with age (r = -0.66, p < 0.01).
- A significant positive correlation was found between urinary calcium and cyclic AMP levels (r = 0.2, p < 0.05).
Conclusions:
- Urinary cyclic AMP excretion decreases with age in healthy children.
- The correlation between urinary calcium and cyclic AMP suggests a potential interplay in pediatric renal physiology.
- These findings provide reference data for urinary calcium and cyclic AMP in healthy children.
Abstract:
The urinary excretion of calcium (mg/g creatinine) and cyclic adenosine 3'5' monophosphate (cyclic AMP) (mumol/g creatinine) was determined in 79 healthy children aged 2 to 12 years. An ag--related pattern to the urinary excretion of calcium was not seen. But urinary cyclic AMP levels are inversely correlated with age (r = -0,66; p less than 0,01) and there is a significant correlation between urinary calcium and cAMP levels (r = 0,2; p less than 0,05).