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Related Experiment Video

Updated: Mar 24, 2026

Postmortem Diagnosis of Rabies in Animals by the Updated, Multiplexed LN34 Real-Time Reverse Transcription-Polymerase Chain Reaction Assay
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Cellular response to rabies virus infection.

F Bussereau, P Perrin

    Comparative Immunology, Microbiology and Infectious Diseases
    |January 1, 1982
    PubMed
    Summary

    Rabies virus does not alter host cell shape or microfilaments, unlike vesicular stomatitis virus. Cytoskeleton does not significantly impact rabies virus production, but affects viral glycosylation.

    Area of Science:

    • Virology
    • Cell Biology
    • Molecular Biology

    Background:

    • Rhabdoviruses, including rabies virus and vesicular stomatitis virus, interact with host cells.
    • Understanding these interactions is crucial for comprehending viral pathogenesis and developing antiviral strategies.

    Purpose of the Study:

    • To investigate and compare the effects of rabies virus and vesicular stomatitis virus on host cell morphology and cytoskeleton.
    • To determine the role of microtubules and microfilaments in rabies virus production.
    • To examine the impact of specific effectors on viral glycosylation.

    Main Methods:

    • Comparative analysis of host cell morphology after infection with rabies virus and vesicular stomatitis virus.
    • Treatment of infected cells with cytoskeleton-disrupting agents (colcemid, colchicine, cytochalasin-B).

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  • Assessment of viral production and virion spike protein glycosylation in treated and untreated cells.

    • Main Results:

    • Rabies virus infection did not affect cell morphology, while vesicular stomatitis virus caused cell retraction and microfilament depolymerization.
    • Microtubules and microfilaments were found not to play a major role in rabies virus production.
    • Cytochalasin-B treatment inhibited glycosylation of the rabies virion spike protein, an effect not observed with vesicular stomatitis virus.

    Conclusions:

    • Rabies virus and vesicular stomatitis virus exhibit distinct interactions with host cell cytoskeleton.
    • Host cell cytoskeleton organization is not a primary determinant of rabies virus production.
    • Differential effects on virion protein glycosylation highlight distinct rhabdovirus-host cell interactions.