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Infection of marmosets with parainfluenza virus types 1 and 3

J D Hawthorne, D Lorenz, P Albrecht

    Infection and Immunity
    |September 1, 1982
    PubMed

    Insights

    Wild marmosets infected with parainfluenza virus types 1 and 3 developed acute respiratory illness. While serum antibodies formed, local secretory antibodies were absent, and the infection spread to other animals.

    Area of Science:

    • Virology
    • Infectious Diseases
    • Primate Models

    Background:

    • Parainfluenza viruses (PIVs) are significant human respiratory pathogens.
    • Understanding PIV infection in non-human primates can provide insights into disease mechanisms and host responses.

    Purpose of the Study:

    • To investigate the effects of parainfluenza virus types 1 and 3 infection in wild marmosets (Saguinus mystax).
    • To characterize the viral replication, antibody response, and transmissibility of PIVs in this primate model.

    Main Methods:

    • Wild marmosets were inoculated with parainfluenza virus types 1 and 3.
    • Respiratory infection, virus replication in the upper respiratory tract, and serum/secretory antibody development were assessed.
    • Transmissibility to susceptible animals was evaluated.

    Main Results:

    • Infection led to acute respiratory illness in marmosets.
    • Virus replication was comparable to that observed in children with PIV infections.
    • Serum antibodies were detected for both virus types, but local secretory antibodies were not.
    • The infection was transmissible to other marmosets for up to 3 days post-inoculation.

    Conclusions:

    • Wild marmosets serve as a relevant model for studying parainfluenza virus respiratory infections.
    • The observed antibody response pattern (serum positive, secretory negative) may inform understanding of PIV pathogenesis.
    • The transmissibility highlights the potential for PIV spread within susceptible populations.

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