[Pancreatic dose-response curves to cholecystokinin in dogs (author's transl)]

Dose-response (DR) curves for pancreatic flow rate, bicarbonate and protein output to cholecystokinin (CCK) were determined by two techniques in 3 conscious dogs with gastric and duodenal Thomas fistulas. With the continuous DR technique the dose of CCK was doubled each 45 minutes and with the single DR technique, only one dose of CCK was infused on each test day. The dose-response curves for pancreatic flow rate and bicarbonate output did not differ with the two techniques. The maximal protein output was higher with the single DR than with the continuous DR technique.