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[Transfer of cefotiam into the tissues of gynecological organs]
Uterine infections, particularly myometritis have been shown to be severe because of the difficult passage of the antibiotics into the affected tissues. Consequently, a biochemically novel drug, cefotiam (CTM) was investigated for the distribution into the uterine body, uterine cervix, ovary and oviduct of 10 patients with benign tumor, 1 g of CTM in 250 ml of 5% glucose was infused for 2 hours. The mean concentration of the antibiotics in the serum, uterine body, uterine cervix, ovary and oviduct at 30 minutes after the intravenous drip infusion was, respectively 19.7 micrograms/ml, 10.1 micrograms/g, 12.9 micrograms/g, 10.7 micrograms/g and 11.7 micrograms/g. The concentration ratio of the tissue to serum was found to be relatively high (51.5--65.5%), as compared to other antibiotics. In this experiments, no adverse effects, such as laboratory findings were found.
Uterine infections, particularly myometritis have been shown to be severe because of the difficult passage of the antibiotics into the affected tissues. Consequently, a biochemically novel drug, cefotiam (CTM) was investigated for the distribution into the uterine body, uterine cervix, ovary and oviduct of 10 patients with benign tumor, 1 g of CTM in 250 ml of 5% glucose was infused for 2 hours. The mean concentration of the antibiotics in the serum, uterine body, uterine cervix, ovary and oviduct at 30 minutes after the intravenous drip infusion was, respectively 19.7 micrograms/ml, 10.1 micrograms/g, 12.9 micrograms/g, 10.7 micrograms/g and 11.7 micrograms/g. The concentration ratio of the tissue to serum was found to be relatively high (51.5--65.5%), as compared to other antibiotics. In this experiments, no adverse effects, such as laboratory findings were found.