Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Interaction between calcium antagonists and vascular postsynaptic alpha-receptors].

J C van Meel, P B Timmermans, P A van Zwieten

    Journal De Pharmacologie
    |July 1, 1982
    PubMed
    Summary

    Calcium antagonists (CA) selectively inhibit alpha 2-adrenoceptor-mediated vasoconstriction by blocking calcium influx, explaining their vasodilator activity. This interaction diminishes the pressor effect of alpha 2-agonists but not alpha 1-agonists.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Hypotensive effects of the angiotensin II antagonist telmisartan in conscious chronically-instrumented transgenic rats.

    Arzneimittel-Forschung·1996
    Same author

    Morphology and function of dog arterial grafts preserved in UW-solution.

    European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery·1995
    Same author

    Low concentrations of UD-CG 212 enhance myocyte contractility by an increase in calcium responsiveness in the presence of inorganic phosphate.

    Naunyn-Schmiedeberg's archives of pharmacology·1995
    Same author

    Sensitivity of cardiac tissues with moderate and advanced hypertrophy to calcium ions.

    General pharmacology·1995
    Same author

    Effects of pimobendan and its metabolite on myofibrillar calcium responsiveness and ATPase activity in the presence of inorganic phosphate.

    Arzneimittel-Forschung·1995
    Same author

    Assessment of peripheral vascular effects of antimigraine drugs in humans.

    Cephalalgia : an international journal of headache·1995

    Area of Science:

    • Pharmacology
    • Cardiovascular Physiology
    • Cellular Biology

    Context:

    • Vascular smooth muscle contraction is regulated by various receptor systems.
    • Calcium antagonists (CA) are widely used antihypertensive drugs.
    • Adrenoceptors, particularly alpha-1 and alpha-2 subtypes, play a critical role in vascular tone.

    Purpose:

    • To review the cellular mechanisms underlying the vascular action of calcium antagonists.
    • To investigate the interaction between calcium antagonists and postsynaptic alpha 2-adrenoceptors in resistance vessels.
    • To elucidate the selective inhibition of alpha 2-adrenoceptor-mediated vasoconstriction by calcium antagonists.

    Summary:

    • Calcium antagonists interfere with postsynaptic alpha 2-adrenoceptors in resistance vessels, diminishing the pressor effect of alpha 2-adrenoceptor agonists.

    Related Experiment Videos

  • This interaction is selective for alpha 2-adrenoceptors, as vasoconstriction induced by alpha 1-adrenoceptor agonists is minimally affected by calcium antagonists.
  • The proposed mechanism involves the inhibition of extracellular calcium influx, essential for contractile protein activation, following alpha 2-adrenoceptor/agonist complex formation.

    • Impact:

    • Provides a cellular-level explanation for the vasodilator activity of calcium antagonists.
    • Highlights the selective inhibition of alpha 2-receptor-mediated vasoconstriction, differentiating it from alpha 1-receptor effects.
    • Contributes to understanding the complex interplay between calcium channels and adrenoceptors in regulating vascular function.