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Related Experiment Videos

Involvement of catecholamines in Haemophilus influenzae induced decrease of beta-adrenoceptor function.

A J Schreurs, D H Versteeg, F P Nijkamp

    Naunyn-Schmiedeberg'S Archives of Pharmacology
    |September 1, 1982
    PubMed
    Summary
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    Haemophilus influenzae vaccination impairs airway relaxation in guinea pigs. Benserazide prevented this desensitization by affecting catecholamine release, suggesting a role for catecholamines in beta-adrenoceptor desensitization.

    Area of Science:

    • Pharmacology
    • Respiratory Medicine
    • Immunology

    Background:

    • Asthmatic bronchitis patients often experience Haemophilus influenzae infections in their airways.
    • Previous studies show H. influenzae vaccination impairs isoproterenol-induced relaxation of guinea pig tracheal spirals.

    Purpose of the Study:

    • To investigate the effects of drugs influencing catecholamine release on H. influenzae-induced desensitization of tracheal spirals.
    • To explore the role of catecholamine metabolism in H. influenzae-mediated airway dysfunction.

    Main Methods:

    • Guinea pigs were vaccinated with H. influenzae.
    • Tracheal spirals were isolated and tested for isoproterenol-induced relaxation.
    • Effects of benserazide (dopa-decarboxylase inhibitor) and desipramine (catecholamine re-uptake inhibitor) were assessed.

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  • Catecholamine levels and release in lung tissue and plasma were measured.

    • Main Results:

    • H. influenzae vaccination significantly reduced isoproterenol-induced relaxation.
    • Benserazide completely prevented this reduction in vaccinated animals.
    • Desipramine did not affect relaxation in vaccinated animals but decreased it in controls.
    • Norepinephrine levels increased in lung and plasma one day post-vaccination.
    • Spontaneous release of catecholamines from tracheal incubates increased post-vaccination.

    Conclusions:

    • Catecholamine metabolism is altered in the lungs of H. influenzae-vaccinated guinea pigs.
    • Catecholamines likely contribute to the desensitization of beta-adrenoceptors induced by H. influenzae.