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Related Experiment Video

Updated: Jul 24, 2026

Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay

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Published on: September 9, 2012

Plasma vanadium concentration in manic-depressive illness.

D A Dick, G J Naylor, E G Dick

Psychological Medicine

|August 1, 1982

Summary

Plasma vanadium levels are higher in individuals with manic-depressive illness compared to controls. This suggests vanadium may influence sodium pump activity linked to mood disorders.

Area of Science:

Biochemistry
Neuroscience
Clinical Chemistry

Background:

Manic-depressive illness (now known as bipolar disorder) is associated with alterations in cellular ion transport.
The role of trace elements in neurological and psychiatric conditions is an area of ongoing research.

Purpose of the Study:

To investigate plasma vanadium concentrations in individuals with manic-depressive illness.
To explore the relationship between plasma vanadium and ATPase activity in these subjects.

Main Methods:

Plasma samples from 9 normal controls and 8 manic-depressive subjects were analyzed.
Atomic absorption spectrometry was used to quantify vanadium levels.
Na-K-Mg ATPase and Mg-ATPase activities were measured and their ratios calculated.

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Main Results:

Mean plasma vanadium was significantly higher in manic (0.34 microM) and depressed (0.28 microM) subjects compared to normal controls (0.15 microM).
Vanadium levels in recovered manic-depressive subjects (0.23 microM) were also elevated compared to controls.
A significant negative correlation was observed between plasma vanadium and the Na-K-Mg ATPase/Mg-ATPase ratio in manic-depressive subjects.

Conclusions:

Elevated plasma vanadium concentrations are associated with manic-depressive illness.
Vanadium may play a role in the observed abnormalities of Na-K-Mg ATPase and sodium pump activity in bipolar disorder.
Further research is warranted to elucidate the precise mechanisms linking vanadium to mood disorders.