Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Plasma vanadium concentration in manic-depressive illness.

D A Dick, G J Naylor, E G Dick

    Psychological Medicine
    |August 1, 1982
    PubMed
    Summary

    Plasma vanadium levels are higher in individuals with manic-depressive illness compared to controls. This suggests vanadium may influence sodium pump activity linked to mood disorders.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Lack of association between mortality and timing of surgical fixation in elderly patients with hip fracture: results of a retrospective population-based cohort study.

    Medical care·2006
    Same author

    Are the fossil data really at odds with the molecular data? Morphological evidence for cetartiodactyla phylogeny reexamined.

    Systematic biology·2002
    Same author

    Amphioxus mitochondrial DNA, chordate phylogeny, and the limits of inference based on comparisons of sequences.

    Systematic biology·2002
    Same author

    Conflicting phylogenetic patterns caused by molecular mechanisms in mitochondrial DNA sequences.

    Systematic biology·2002
    Same author

    A model for phylogenetic inference using structural and chemical covariates.

    Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing·2001
    Same author

    Measuring shifts in function and evolutionary opportunity using variability profiles: a case study of the globins.

    Journal of molecular evolution·2000

    Area of Science:

    • Biochemistry
    • Neuroscience
    • Clinical Chemistry

    Background:

    • Manic-depressive illness (now known as bipolar disorder) is associated with alterations in cellular ion transport.
    • The role of trace elements in neurological and psychiatric conditions is an area of ongoing research.

    Purpose of the Study:

    • To investigate plasma vanadium concentrations in individuals with manic-depressive illness.
    • To explore the relationship between plasma vanadium and ATPase activity in these subjects.

    Main Methods:

    • Plasma samples from 9 normal controls and 8 manic-depressive subjects were analyzed.
    • Atomic absorption spectrometry was used to quantify vanadium levels.
    • Na-K-Mg ATPase and Mg-ATPase activities were measured and their ratios calculated.

    Main Results:

    • Mean plasma vanadium was significantly higher in manic (0.34 microM) and depressed (0.28 microM) subjects compared to normal controls (0.15 microM).
    • Vanadium levels in recovered manic-depressive subjects (0.23 microM) were also elevated compared to controls.
    • A significant negative correlation was observed between plasma vanadium and the Na-K-Mg ATPase/Mg-ATPase ratio in manic-depressive subjects.

    Conclusions:

    • Elevated plasma vanadium concentrations are associated with manic-depressive illness.
    • Vanadium may play a role in the observed abnormalities of Na-K-Mg ATPase and sodium pump activity in bipolar disorder.
    • Further research is warranted to elucidate the precise mechanisms linking vanadium to mood disorders.

    Related Experiment Videos