[Adenylate kinase activity of the blood of irradiated rats]

The direct and reverse adenylate kinase reactions were studied in blood of rats 1, 3, 7, 15 and 30 days after total X-ray irradiation with a dose of 154.8 mC/kg (600 R) dose. It is found out that adenylate kinase (CE 2.7.4.3) activity in leucocytes and erythrocytes is inhibited on the 3d, 7th and 15th days of the study. Inhibition of the reverse adenylate kinase reaction is pronounced to a greater extent than that of the direct one. The adenylate kinase of erythrocytes is more stable to the effect of ionizing radiations as compared to this enzyme of leucocytes. When the enzymic activity in the blood cells is inhibited, the activity of the direct adenylate kinase reaction in the serum increases significantly and that of the reverse one remains unchanged.