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Related Experiment Videos

Why does anyone still use desiccated thyroid USP?

I M Jackson, W E Cobb

    The American Journal of Medicine
    |February 1, 1978
    PubMed
    Summary
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    Switching from thyroid USP to sodium L-thyroxine improves thyroid hormone levels. Thyroid USP can cause misleading hormone estimates and thyrotoxic symptoms, while sodium L-thyroxine offers better assessment.

    Area of Science:

    • Endocrinology
    • Pharmacology

    Background:

    • Thyroid hormone replacement therapy is crucial for managing hypothyroidism.
    • Thyroid USP, a desiccated thyroid extract, contains both thyroxine (T4) and triiodothyronine (T3).
    • Sodium L-thyroxine is a synthetic form of T4, a commonly prescribed thyroid hormone medication.

    Purpose of the Study:

    • To evaluate the impact of switching from thyroid USP to sodium L-thyroxine on thyroid status.
    • To compare serum triiodothyronine (T3) and thyroxine (T4) levels between the two medications.
    • To assess the clinical significance of observed hormonal changes, including thyrotoxic symptoms.

    Main Methods:

    • A study involving 40 patients transitioning from thyroid USP to sodium L-thyroxine.
    • Measurement of serum T3 and T4 levels before and after the medication switch.

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  • Clinical assessment for the presence and severity of thyrotoxic symptoms.

    • Main Results:

    • Patients on thyroid USP (90-240 mg) exhibited abnormally high T3 levels (289 ng/dl) and lower T4 levels (7.4 microgram/dl).
    • Switching to sodium L-thyroxine (0.15-0.2 mg) resulted in significantly lower T3 (176 ng/dl) and higher T4 (11.6 microgram/dl) levels.
    • Six patients experienced thyrotoxic symptoms with thyroid USP, which resolved after changing to sodium L-thyroxine.

    Conclusions:

    • Thyroid USP can lead to misleading thyroid function estimates and potentially cause thyrotoxic symptoms due to elevated T3.
    • Sodium L-thyroxine provides a more accurate assessment of thyroid hormone replacement, with T4 and T3 levels being reliable indicators.
    • Discontinuation of thyroid USP is recommended due to its potential for adverse effects and inaccurate hormonal profiles.