Related Experiment Videos
[Ineffectiveness of high-dosage methotrexate in patients with small cell bronchial cancer]
Onkologie
|August 1, 1982
Abstract:
5 patients with small-cell lung cancer were treated with high-dose methotrexate (1.75-16 g). No significant tumor reduction could be demonstrated. High-dose methotrexate therapy cannot be recommended for the treatment of small-cell lung cancer. Other established and successful regimens are available.
Insights
High-dose methotrexate therapy showed no significant tumor reduction in five patients with small-cell lung cancer. This treatment is not recommended due to the availability of more successful regimens.
Area of Science:
- Oncology
- Pharmacology
Context:
- Small-cell lung cancer (SCLC) is an aggressive form of lung cancer.
- Chemotherapy is a primary treatment modality for SCLC.
Purpose:
- To evaluate the efficacy of high-dose methotrexate in patients with small-cell lung cancer.
Summary:
- Five patients with small-cell lung cancer received high-dose methotrexate (1.75-16 g).
- No significant tumor reduction was observed in any of the treated patients.
Impact:
- High-dose methotrexate is not recommended for small-cell lung cancer treatment.
- Established and successful alternative chemotherapy regimens exist for SCLC.