Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Properties of thyroidectomized rat extensor muscle.

J Grossie

    The American Journal of Physiology
    |March 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Thyroid removal in rats alters muscle properties, affecting twitch tension and increasing action potential duration. Electrical changes in muscle fibers were observed, with decreased potassium and chloride conductance.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Dopamine inhibits a sustained calcium current through activation of alpha adrenergic receptors and a GTP-binding protein in adult rat sympathetic neurons.

    The Journal of pharmacology and experimental therapeutics·1994
    Same author

    Ca-dependent action of cocaine on K current in freshly dissociated dorsal root ganglia from rats.

    The American journal of physiology·1993
    Same author

    Chloride distribution in rat extensor digitorum longus muscle.

    Progress in clinical and biological research·1990
    Same author

    Bicarbonate and fast-twitch muscle: evidence for a major role in pH regulation.

    The Journal of membrane biology·1988
    Same author

    Effects of bicarbonate on resting potentials in mammalian skeletal muscle.

    Journal of cellular physiology·1985
    Same author

    Skeletal muscle in alloxan diabetes. A comparison of isometric contractions in fast and slow muscle.

    Diabetes·1983
    Same journal

    Blood coagulation in fish.

    The American journal of physiology·2011
    Same journal

    Renal tubular reabsorption, metabolic utilization and isomeric fractionation of lactic acid in the dog.

    The American journal of physiology·2010
    Same journal

    The inactivation of placental toxin by human serum.

    The American journal of physiology·2010
    Same journal

    Adrenal function following ovariectomy in the rat.

    The American journal of physiology·2010
    Same journal

    Capillary permeability; perfusion of frog and guinea pig hind limbs.

    The American journal of physiology·2010
    Same journal

    Evaluation of protective measures against sunburn.

    The American journal of physiology·2010
    See all related articles

    Area of Science:

    • Physiology
    • Muscle Biology
    • Endocrinology

    Background:

    • Thyroid hormones play a crucial role in regulating skeletal muscle function.
    • Thyroid dysfunction can lead to significant alterations in muscle physiology and performance.

    Purpose of the Study:

    • To investigate the effects of thyroid removal on the mechanical and electrical properties of rat extensor muscles.
    • To understand the underlying changes in muscle fiber membrane characteristics and ionic conductances.

    Main Methods:

    • Analysis of isometric twitch tensions and tetanic force in thyroidectomized (Tx) rat extensor muscles.
    • Intracellular electrophysiological recordings to assess resting membrane potential, action potentials, and membrane properties.
    • Estimation of specific ionic conductances (potassium and chloride).

    Related Experiment Videos

    Main Results:

    • Thyroidectomy led to variable isometric twitch tensions, with a significant increase in twitch duration.
    • Action potentials exhibited higher overshoots, amplitudes, and rates of depolarization in Tx rats.
    • Increased input resistance, space constant, time constant, and specific membrane resistance were observed, alongside decreased fiber diameter and capacitance.
    • Estimates indicated decreased potassium and chloride conductance in Tx rat muscle.

    Conclusions:

    • Thyroid removal profoundly impacts rat extensor muscle mechanics and electrophysiology.
    • Alterations in membrane properties and reduced ionic conductances contribute to the observed functional changes.
    • These findings highlight the critical role of thyroid hormones in maintaining normal skeletal muscle function.