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[Gonadotropin and plasma cyclic nucleotides].

T Fujiwara, K Katayama, S Tojo

    Nihon Sanka Fujinka Gakkai Zasshi
    |November 1, 1982
    PubMed
    Summary
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    Human chorionic gonadotropin (HCG) significantly increases plasma cyclic adenosine monophosphate (cAMP) levels, even in castrated women. HCG also impacts thyroid hormones, increasing triiodothyronine (T3) in castrated women.

    Area of Science:

    • Endocrinology
    • Reproductive Biology
    • Biochemistry

    Context:

    • Plasma cyclic nucleotides, specifically cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP), play crucial roles in various physiological processes.
    • Understanding the regulation of these nucleotides by hormones is essential for comprehending reproductive and endocrine functions.

    Purpose:

    • To investigate the physiological variations of plasma cyclic AMP and cyclic GMP in women under different conditions, including the menstrual cycle and pregnancy.
    • To determine the effects of gonadotropins, specifically human menopausal gonadotropin (HMG) and human chorionic gonadotropin (HCG), on plasma cyclic AMP levels in normal and castrated women.
    • To explore the extragonadal effects of HCG on plasma levels of cortisol, triiodothyronine (T3), and thyroxine (T4).

    Summary:

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    • Plasma cAMP exhibits a circadian rhythm and varies during the menstrual cycle in normal women, increasing significantly during pregnancy.
    • Neither HMG nor HCG alone altered plasma cAMP in normal women, but HCG administration, alone or with HMG, significantly increased plasma cAMP in both normal and castrated women.
    • HCG administration did not affect plasma cortisol levels but led to a marked increase in T3 and a slight decrease in T4 in castrated women, suggesting extragonadal effects.

    Impact:

    • This study elucidates the specific role of HCG in modulating plasma cAMP levels, independent of ovarian function.
    • The findings highlight potential extragonadal actions of HCG, particularly its influence on thyroid hormone regulation in the absence of gonads.
    • Provides insights into the hormonal regulation of cyclic nucleotides and their implications in reproductive endocrinology and potential therapeutic applications.