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Brain cyclic AMP and memory in mice.

C T Randt, M E Judge, K A Bonnet

    Pharmacology, Biochemistry, and Behavior
    |October 1, 1982
    PubMed
    Summary
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    Rolipram, a phosphodiesterase inhibitor, reversed amnesia and improved memory retention when given immediately after training. This suggests cyclic AMP plays a crucial role in memory processes.

    Area of Science:

    • Neuroscience
    • Molecular Biology
    • Pharmacology

    Background:

    • Protein synthesis inhibitors like anisomycin can induce amnesia for learned responses.
    • Phosphodiesterase inhibitors can modulate intracellular signaling pathways.

    Purpose of the Study:

    • To investigate the effect of Rolipram, a phosphodiesterase inhibitor, on memory consolidation and retrieval.
    • To explore the role of cyclic AMP (cAMP) in memory formation.

    Main Methods:

    • Rolipram (10 mg/kg IP) was administered immediately or 3 hours post-training in an inhibitory avoidance task.
    • Amnesia was induced using the protein synthesis inhibitor anisomycin.
    • Cyclic AMP (cAMP) and cyclic GMP (cGMP) levels were measured in brain regions of treated mice.

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    Main Results:

    • Immediate post-training administration of Rolipram reversed anisomycin-induced amnesia.
    • Rolipram administration also enhanced retention of a weakly learned avoidance response.
    • Rolipram treatment led to elevated cAMP levels in the frontal cortex, thalamus, and hypothalamus, but not cGMP.

    Conclusions:

    • Rolipram's ability to reverse amnesia and enhance memory suggests a role for phosphodiesterase inhibition in memory processes.
    • Elevated cAMP levels following Rolipram administration support the hypothesis that cAMP is involved in memory formation and consolidation.