Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Effect of glycerol on the EP decrease caused by furosemide.

M Ohmura, N Yagi, N Kanoh

    Acta Oto-Laryngologica
    |November 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Novel method for endovascular fenestration using radiofrequency transseptal needle for aortic dissection with malperfusion syndrome.

    Radiology case reports·2020
    Same author

    Self-harm and Suicide Attempts in a Japanese Psychiatric Hospital.

    East Asian archives of psychiatry : official journal of the Hong Kong College of Psychiatrists = Dong Ya jing shen ke xue zhi : Xianggang jing shen ke yi xue yuan qi kan·2018
    Same author

    Erratum to: Predictors of poor sleep quality in patients with systemic lupus erythematosus.

    Clinical rheumatology·2017
    Same author

    The TriAGe+ Score for Vertigo or Dizziness: A Diagnostic Model for Stroke in the Emergency Department.

    Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association·2017
    Same author

    Predictors of poor sleep quality in patients with systemic lupus erythematosus.

    Clinical rheumatology·2017
    Same author

    The Japanese LupusPRO: A cross-cultural validation of an outcome measure for lupus.

    Lupus·2016

    Glycerol potentiates furosemide's effect on endocochlear potential (EP) in guinea pigs. This suggests glycerol may enhance furosemide delivery to the stria vascularis, impacting EP levels.

    Area of Science:

    • Ototoxicology
    • Auditory Physiology

    Background:

    • The endocochlear potential (EP) is crucial for hearing.
    • Furosemide is a diuretic known to affect EP.

    Purpose of the Study:

    • To investigate the effect of glycerol on furosemide-induced changes in EP.
    • To determine if glycerol administration alters the ototoxic effects of furosemide.

    Main Methods:

    • Two groups of guinea pigs were used.
    • One group received varying doses of furosemide (20-50 mg/kg).
    • The second group received glycerol followed by furosemide (20-40 mg/kg).
    • Endocochlear potential (EP) was measured in both groups.

    Main Results:

    • A significant potentiation of furosemide's EP-lowering effect was observed in the glycerol-furosemide group.

    Related Experiment Videos

  • The decrease in EP was approximately 40% greater in animals pre-treated with glycerol.
  • This indicates glycerol enhances the impact of furosemide on EP.

    • Conclusions:

    • Glycerol potentiates the EP-lowering action of furosemide.
    • Glycerol may facilitate furosemide's access to the stria vascularis, its primary site of action.
    • This interaction could have implications for understanding ototoxicity and drug delivery in the inner ear.