Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Oxygen radicals.

A M Michelson

    Agents and Actions. Supplements
    |January 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    Superoxide radicals contribute to inflammation by damaging cells and activating inflammatory factors. Superoxide dismutases show potential for treating inflammatory conditions, with delivery methods impacting effectiveness.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    rolling pebbles (rols) is required in Drosophila muscle precursors for recruitment of myoblasts for fusion.

    Development (Cambridge, England)·2001
    Same author

    Invertebrate myogenesis: looking back to the future of muscle development.

    Current opinion in genetics & development·2001
    Same author

    Ras pathway specificity is determined by the integration of multiple signal-activated and tissue-restricted transcription factors.

    Cell·2000
    Same author

    Exposure of Mn and FeSODs, but not Cu/ZnSOD, to NO leads to nitrosonium and nitroxyl ions generation which cause enzyme modification and inactivation: an in vitro study.

    Free radical biology & medicine·1999
    Same author

    Heparan sulfate proteoglycans are essential for FGF receptor signaling during Drosophila embryonic development.

    Development (Cambridge, England)·1999
    Same author

    Combinatorial signaling codes for the progressive determination of cell fates in the Drosophila embryonic mesoderm.

    Genes & development·1998

    Area of Science:

    • Biochemistry
    • Immunology
    • Cell Biology

    Background:

    • Superoxide radicals (O2•−) are implicated in inflammation through excessive production by immune cells during phagocytosis.
    • These radicals contribute to inflammation by activating neutrophil chemotactic factors and causing DNA damage.
    • Superoxide radicals can also activate clastogenic factors, particularly relevant in autoimmune diseases and radiation exposure.

    Purpose of the Study:

    • To explore the role of superoxide radicals in inflammatory processes.
    • To investigate the therapeutic potential of superoxide dismutases (SODs) in managing inflammatory conditions.
    • To evaluate factors influencing the pharmacological application of SODs, including delivery methods.

    Main Methods:

    • Review of the biochemical roles of superoxide radicals in inflammation.

    Related Experiment Videos

  • Discussion of the potential therapeutic applications of superoxide dismutases.
  • Examination of experimental results using free and liposomal-encapsulated SOD.

    • Main Results:

    • Superoxide radicals are involved in multiple stages of inflammation, including immune cell activity and genetic damage.
    • Superoxide dismutases demonstrate potential for treating chronic inflammatory diseases.
    • Factors such as circulation time, cell penetration, and intracellular localization are critical for SOD efficacy.
    • Liposomal encapsulation may enhance the delivery and effectiveness of SOD.

    Conclusions:

    • Superoxide radicals are key mediators in the biochemistry of inflammation.
    • Superoxide dismutases offer a promising therapeutic strategy for inflammatory disorders.
    • Optimizing the delivery and pharmacokinetic properties of SOD is essential for clinical success.
    • Further research into enzymatic systems for oxidative stress management holds future medical promise.