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Related Experiment Videos

Cefotaxime in human lung tissue.

R Blind, A Bikfalvi, K Seeger

    Arzneimittel-Forschung
    |January 1, 1982
    PubMed
    Summary
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    This study measured cefotaxime levels in lung tissue after thoracic surgery. Cefotaxime was detectable for hours, highlighting its persistence in tissue following intravenous administration.

    Area of Science:

    • Pharmacology and Therapeutics
    • Surgical Oncology
    • Clinical Microbiology

    Background:

    • Understanding antibiotic penetration into surgical sites is crucial for effective infection prevention.
    • Cefotaxime is a widely used cephalosporin antibiotic in surgical settings.
    • Accurate measurement of antibiotic concentrations in target tissues is essential for pharmacokinetic analysis.

    Purpose of the Study:

    • To determine cefotaxime concentrations in lung tissue following intravenous administration during thoracic surgery.
    • To evaluate the duration of cefotaxime presence in lung tissue.
    • To address challenges in measuring ester cephalosporins in biological samples.

    Main Methods:

    • Lung tissue samples were collected from 79 patients undergoing thoracic surgery.

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  • Patients received either 1g or 2g of intravenous cefotaxime.
  • Cefotaxime levels in tissue were quantified using a microbiological assay at various time points (2 and 4 hours post-injection).

    • Main Results:

    • Median cefotaxime concentrations of 1.6 and 5.1 microgram/g were observed approximately 1 hour after 1g and 2g doses, respectively.
    • Cefotaxime was detectable in lung tissue at later time points.
    • The study noted potential interference from desacetylation in hemolytic samples when measuring ester cephalosporins.

    Conclusions:

    • Intravenous cefotaxime achieves measurable concentrations in lung tissue during thoracic surgery.
    • Cefotaxime persists in lung tissue for several hours post-administration.
    • Further research is needed to refine measurement techniques for ester cephalosporins in biological tissues.