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Heredity of chronic polymorphous light eruptions.

C T Jansén

    Archives of Dermatology
    |February 1, 1978
    PubMed
    Summary

    Chronic polymorphous light eruptions (CPLE) often run in families, suggesting a genetic link. Atopy may influence the expression of this light-sensitive skin condition.

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    Area of Science:

    • Dermatology
    • Genetics
    • Epidemiology

    Background:

    • Chronic polymorphous light eruptions (CPLE) are a group of idiopathic photodermatoses.
    • Familial occurrence suggests a genetic predisposition.

    Purpose of the Study:

    • To investigate the familial occurrence and inheritance patterns of CPLE.
    • To determine the mode of inheritance and penetrance of CPLE.

    Main Methods:

    • A thorough interrogation of 91 CPLE patients was conducted.
    • Genealogical data was collected and analyzed.
    • Penetrance was estimated in sibships.

    Main Results:

    • 51 out of 91 CPLE patients reported familial cases.
    • Autosomal dominant inheritance with reduced penetrance was suggested.
    • The estimated penetrance rate was 52% in sibships.
    • Atopic trait was found to promote CPLE manifestation.

    Conclusions:

    • CPLE exhibits familial aggregation, likely due to autosomal dominant inheritance.
    • Reduced penetrance is a characteristic of CPLE inheritance.
    • Atopy is a potential factor influencing CPLE expression.

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