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Related Experiment Videos

Relationship between arsenic intake and internal malignant neoplasms.

F Reymann, R Moller, A Nielsen

    Archives of Dermatology
    |March 1, 1978
    PubMed
    Summary

    Arsenic exposure, even at low dermatological doses, may increase cancer risk. This study observed a higher incidence of internal cancers in females with multiple basal cell carcinomas who were treated with arsenic.

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    Area of Science:

    • Environmental Health
    • Dermatology
    • Oncology

    Background:

    • Arsenic has been used historically for treating various skin conditions.
    • Concerns exist regarding the potential long-term health effects of arsenic exposure, including carcinogenicity.

    Purpose of the Study:

    • To evaluate the carcinogenic potential of arsenic intake from dermatological treatments administered in the 1930s.
    • To compare cancer incidence in treated patients with general population data.

    Main Methods:

    • Analysis of a cohort of patients treated with arsenic for skin diseases.
    • Comparison of observed internal malignant neoplasm incidence with data from the Danish Cancer Registry.
    • Examination of a subgroup with arsenic keratoses for cancer incidence.

    Main Results:

    • A significant increase in internal malignant neoplasms was found in females with multiple basal cell carcinomas.
    • Patients with arsenic keratoses showed a notable increase in internal malignant neoplasms, though statistical analysis was limited.
    • Findings suggest arsenic possesses carcinogenic effects even at therapeutic doses.

    Conclusions:

    • Arsenic exposure from dermatological therapy is associated with an increased risk of internal cancers.
    • The study supports the hypothesis that arsenic is a carcinogen, even at low therapeutic doses.

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