Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Environmental modifiers in carcinogenesis.

H C Pitot

    IARC Scientific Publications
    |January 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    Understanding cancer development requires examining its stages: initiation, promotion, and progression. Identifying promoting agents is key to preventing cancer, as their effects are reversible and distinct from carcinogens.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    A prospective genome-wide study of prostate cancer metastases reveals association of wnt pathway activation and increased cell cycle proliferation with primary resistance to abiraterone acetate-prednisone.

    Annals of oncology : official journal of the European Society for Medical Oncology·2017
    Same author

    Treatment of neuroendocrine cancer metastatic to the liver: the role of ablative techniques.

    Cardiovascular and interventional radiology·2005
    Same author

    Bioinformatics approaches for cross-species liver cancer analysis based on microarray gene expression profiling.

    BMC bioinformatics·2005
    Same author

    Gemcitabine and oxaliplatin for metastatic pancreatic adenocarcinoma: a North Central Cancer Treatment Group phase II study.

    Annals of oncology : official journal of the European Society for Medical Oncology·2003
    Same author

    A phase I study of sequential irinotecan and 5-fluorouracil/leucovorin.

    Annals of oncology : official journal of the European Society for Medical Oncology·2002
    Same author

    Gemcitabine and oxaliplatin for patients with advanced or metastatic pancreatic cancer: a North Central Cancer Treatment Group (NCCTG) phase I study.

    Annals of oncology : official journal of the European Society for Medical Oncology·2002
    Same journal

    North America.

    IARC scientific publications·2016
    Same journal

    Central and South America.

    IARC scientific publications·2016
    Same journal

    Africa.

    IARC scientific publications·2016
    Same journal

    Data availability and presentation.

    IARC scientific publications·2016
    Same journal

    Age standardization.

    IARC scientific publications·2016
    Same journal

    Data processing.

    IARC scientific publications·2016
    See all related articles

    Area of Science:

    • Oncology
    • Carcinogenesis Research

    Background:

    • Neoplastic development progresses through distinct stages: initiation, promotion, and progression.
    • Morphological techniques allow identification of all stages, from precursor lesions to malignancy, in humans and animals.

    Purpose of the Study:

    • To highlight the critical role of the promotion stage in regulating neoplastic development.
    • To emphasize the importance of identifying environmental promoting agents for cancer prevention.

    Main Methods:

    • Biological experimentation and histopathological characterization to define stages of neoplastic development.
    • Identification of selective promoting agents in experimental systems and human studies.

    Main Results:

    • The promotion stage is the primary target for regulating cancer development.

    Related Experiment Videos

  • Promoting agents have been identified across various tissue types.
  • Promoting agent activity shows threshold and maximal levels and is reversible.

    • Conclusions:

    • Identifying environmental promoting agents is crucial for understanding and preventing human cancer.
    • Promoting agents' distinct action from carcinogens must be considered in risk assessment.