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Related Experiment Videos

Peripheral neuropathy associated with polycythemia vera.

C Yiannikas, J G McLeod, J C Walsh

    Neurology
    |February 1, 1983
    PubMed
    Summary

    Polycythemia vera is associated with peripheral neuropathy. Nerve conduction studies revealed significant sensory nerve impairment and mild motor nerve slowing in affected patients.

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    Recent Studies of the Nervous System.

    Journal of the Royal College of Physicians of London·2019

    Area of Science:

    • Neurology
    • Hematology
    • Peripheral Nervous System Disorders

    Background:

    • Polycythemia vera (PV) is a myeloproliferative neoplasm characterized by increased red blood cell mass.
    • Peripheral neuropathy can manifest as sensory or motor deficits.
    • The relationship between PV and peripheral neuropathy requires further investigation.

    Purpose of the Study:

    • To investigate the presence and characteristics of peripheral neuropathy in patients with polycythemia vera.
    • To assess nerve conduction parameters and histopathological findings in PV patients.

    Main Methods:

    • Nerve conduction studies (NCS) were conducted on 26 patients diagnosed with polycythemia vera.
    • Sensory and motor conduction velocities were evaluated for peripheral nerves.
    • Sural nerve biopsies were performed on a subset of patients for histopathological analysis.

    Main Results:

    • Significant impairment of sensory conduction was observed in the ulnar and sural nerves.
    • Mild slowing of motor conduction was noted in the lateral popliteal nerve.
    • Sural nerve biopsies indicated mild chronic axonal degeneration consistent with peripheral neuropathy.

    Conclusions:

    • There is a notable association between polycythemia vera and the development of peripheral neuropathy.
    • Nerve conduction abnormalities and axonal degeneration are present in PV patients with neuropathy.
    • These findings highlight the importance of evaluating for peripheral nerve dysfunction in polycythemia vera.

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