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[Pathogenesis of the arterial hypertensive syndrome in Itsenko-Cushing disease]
Insights
Patients with Icenko-Cushing's disease experience high blood pressure due to an overactive renin-angiotensin-aldosterone system. This system significantly impacts central hemodynamics, contributing to hypertension in these patients.
Area of Science:
- Endocrinology
- Cardiovascular Physiology
Background:
- Icenko-Cushing's disease is characterized by hormonal imbalances.
- Understanding the interplay between hormonal regulation and cardiovascular function is crucial.
Purpose of the Study:
- To investigate central hemodynamics and the renin-angiotensin-aldosterone system (RAAS) in patients with aggravated Icenko-Cushing's disease.
- To elucidate the relationship between RAAS activity and hemodynamic alterations.
Main Methods:
- Assessment of central hemodynamic indices.
- Measurement of plasma levels of corticotrophin, cortisol, and aldosterone.
- Quantification of plasma renin activity.
Main Results:
- Patients exhibited sustained hypertension and increased total peripheral resistance.
- A decreased cardiac index was observed.
- Elevated levels of corticotrophin, cortisol, aldosterone, and enhanced plasma renin activity were detected.
Conclusions:
- Activation of the RAAS plays a significant role in the development of arterial hypertension in Icenko-Cushing's disease.
- The RAAS significantly influences central hemodynamic parameters in these patients.
Abstract:
The indices of central hemodynamics and renin-angiotensine-aldosterone system, as well as their relationship, were studied in patients with aggravated Icenko-Cushing's disease. A stable high arterial pressure, a raised total peripheral resistance, a decreased cardiac index, an increased blood corticotrophin, cortisol and aldosterone levels and an enhanced plasmatic renin activity were revealed. It is suggested that activation of the renin-angiotensin-aldosterone system stimulates the development of arterial hypertension in patients with Icenko-Cushing's disease, taking into account a significant role of this system in alteration of the central hemodynamics indices.