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Related Experiment Videos

Intraocular irrigating solutions. A comparative study of BSS Plus and lactated Ringer's solution.

H F Edelhauser, R Gonnering, D L Van Horn

    Archives of Ophthalmology (Chicago, Ill. : 1960)
    |March 1, 1978
    PubMed
    Summary

    BSS plus solution effectively maintained human cornea thickness and endothelial cell integrity during perfusion. Lactated Ringer's solution led to significant corneal swelling and cell damage in most cases.

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    Area of Science:

    • Ophthalmology
    • Corneal Science
    • Surgical Solutions

    Background:

    • Maintaining corneal health during eye surgery is critical.
    • Standard perfusion solutions may not adequately protect corneal endothelium.
    • Need for optimized solutions for extended surgical procedures.

    Purpose of the Study:

    • To compare the efficacy of BSS plus and lactated Ringer's solution.
    • To evaluate their impact on human corneal thickness and endothelial integrity.
    • To determine the optimal perfusion solution for long-term corneal preservation during surgery.

    Main Methods:

    • Isolated human corneas were perfused with BSS plus or lactated Ringer's solution.
    • Corneal thickness and endothelial ultrastructure were monitored.

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  • Perfusion duration ranged from three to four hours.

    • Main Results:

    • Corneas perfused with BSS plus maintained normal thickness and endothelial integrity.
    • Five out of six corneas perfused with lactated Ringer's showed swelling and endothelial damage.
    • BSS plus demonstrated superior preservation compared to lactated Ringer's solution.

    Conclusions:

    • BSS plus is a superior solution for preserving human corneal endothelium.
    • It ensures corneal thickness and ultrastructural integrity during extended perfusion.
    • Recommended for use in long-term ophthalmic surgical procedures.