Trilostane in the management of Cushing's syndrome

Trilostane has been used to treat 6 patients with Cushing's syndrome, 4 with an adrenal adenoma and 2 with pituitary driven disease. Three patients responded clinically and biochemically to trilostane. Although effective in some cases of Cushing's syndrome, the variability of the effect of trilostane may limit its usefulness as a therapeutic agent.