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Meningiomas with a non-meningotheliomatous component. A new type of tumour?
Abstract:
Seven cases of meningiomas with "pseudopsammoma bodies" have previously been described in the literature. Two additional cases are presented. Electron microscopy of the cells surrounding the "pseudopsammoma bodies" reveals an ultrastructure different from that of the meningotheliomatous cells. It is concluded that meningotheliomatous meningiomas with "pseudopsammoma bodies" are mixed tumours, including a non-meningotheliomatous component, the origin and significance of which is uncertain.
Insights
Two new cases of meningiomas with pseudopsammoma bodies were studied. Electron microscopy revealed a distinct ultrastructure, suggesting these are mixed tumors with an uncertain non-meningothelial component.
Area of Science:
- Neuropathology
- Oncology
- Cell Biology
Background:
- Meningiomas are tumors arising from the meninges.
- Pseudopsammoma bodies are rare findings in meningiomas.
- Previous literature describes seven cases of meningiomas with pseudopsammoma bodies.
Purpose of the Study:
- To present two additional cases of meningiomas with pseudopsammoma bodies.
- To investigate the ultrastructure of cells associated with pseudopsammoma bodies.
- To determine the nature of pseudopsammoma bodies in meningiomas.
Main Methods:
- Histopathological examination of meningioma tissue.
- Electron microscopy of cells surrounding pseudopsammoma bodies.
Main Results:
- Two new cases of meningiomas exhibiting pseudopsammoma bodies were identified.
- Electron microscopy showed that cells around pseudopsammoma bodies have a different ultrastructure compared to meningothelial cells.
Conclusions:
- Meningiomas with pseudopsammoma bodies are likely mixed tumors.
- These tumors contain a non-meningothelial component of uncertain origin and significance.