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Enzyme alterations in leukemic cells.

N L Dunn, H M Maurer

    American Journal of Hematology
    |December 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    Enzyme alterations in leukemia cells, including terminal deoxynucleotidyl transferase and lysosomal enzymes, show distinct patterns. These biochemical markers aid in diagnosing and classifying lymphoid malignancies.

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    Area of Science:

    • Biochemistry
    • Hematology
    • Oncology

    Background:

    • Leukemic cells exhibit altered enzyme profiles.
    • Key enzymes studied include terminal deoxynucleotidyl transferase, purine pathway enzymes, and lysosomal enzymes like hexosaminidase.

    Purpose of the Study:

    • To investigate enzyme alterations in leukemic cells.
    • To determine the diagnostic and prognostic utility of these enzyme changes in hematopoietic neoplasia, particularly lymphoid malignancies.

    Main Methods:

    • Analysis of total enzyme activities.
    • Examination of isoenzyme patterns in various leukemia types and subtypes.

    Main Results:

    • Significant differences in total enzyme activities and isoenzyme patterns were observed across different leukemia types.

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  • These variations correlate with specific leukemia classifications.

    • Conclusions:

    • Enzyme alterations are characteristic of leukemic cells.
    • These biochemical markers can serve as valuable tools for leukemia diagnosis, classification, and monitoring residual disease.