Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hormonal modulation of glomerular function.

L D Dworkin, I Ichikawa, B M Brenner

    The American Journal of Physiology
    |February 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Is a reduction in albuminuria associated with renal and cardiovascular protection? A post hoc analysis of the ALTITUDE trial.

    Diabetes, obesity & metabolism·2015
    Same author

    Increased serum potassium affects renal outcomes: a post hoc analysis of the Reduction of Endpoints in NIDDM with the Angiotensin II Antagonist Losartan (RENAAL) trial.

    Diabetologia·2010
    Same author

    Renal risk scores: progress and prospects.

    Kidney international·2008
    Same author

    Predicting initiation and progression of chronic kidney disease: Developing renal risk scores.

    Kidney international·2006
    Same author

    Renal risk and renoprotection among ethnic groups with type 2 diabetic nephropathy: a post hoc analysis of RENAAL.

    Kidney international·2006
    Same author

    'Hypertension' and 'microalbuminuria': the bell tolls for thee.

    Kidney international·2005
    Same journal

    Blood coagulation in fish.

    The American journal of physiology·2011
    Same journal

    Renal tubular reabsorption, metabolic utilization and isomeric fractionation of lactic acid in the dog.

    The American journal of physiology·2010
    Same journal

    The inactivation of placental toxin by human serum.

    The American journal of physiology·2010
    Same journal

    Adrenal function following ovariectomy in the rat.

    The American journal of physiology·2010
    Same journal

    Capillary permeability; perfusion of frog and guinea pig hind limbs.

    The American journal of physiology·2010
    Same journal

    Evaluation of protective measures against sunburn.

    The American journal of physiology·2010
    See all related articles

    Glomeruli respond to hormones like angiotensin II (ANG II) and antidiuretic hormone (ADH) via mesangial cell contraction, influencing kidney filtration. These hormonal pathways are key in various kidney injury conditions.

    Area of Science:

    • Nephrology
    • Renal Physiology
    • Endocrinology

    Background:

    • Glomeruli possess hormone receptors, with angiotensin II (ANG II) and antidiuretic hormone (ADH) triggering mesangial cell contraction.
    • Hormones also modulate glomerular cyclic nucleotide synthesis (cAMP, cGMP) and prostaglandin production.
    • Glomeruli are sites of prostaglandin, renin, and ANG II synthesis.

    Purpose of the Study:

    • To investigate the effects of vasoactive drugs and hormones on glomerular filtration using micropuncture studies.
    • To elucidate the mechanisms by which hormones influence the ultrafiltration coefficient (Kf) and glomerular filtration rate (GFR).

    Main Methods:

    • Micropuncture studies were conducted in Munich-Wistar rats.
    • The effects of vasodilators, vasoconstrictors (ANG II, norepinephrine), ADH, and parathyroid hormone on renal plasma flow, Kf, and GFR were examined.

    Related Experiment Videos

    Main Results:

    • Vasodilators increased renal plasma flow but did not alter GFR due to a decreased Kf.
    • Vasoconstrictors (ANG II, norepinephrine) reduced renal plasma flow and Kf, maintaining constant GFR via increased hydraulic pressure.
    • ADH and parathyroid hormone were found to reduce Kf.

    Conclusions:

    • Glomerular mesangial cells regulate Kf by altering glomerular capillary surface area through contraction.
    • ANG II and ADH directly induce mesangial cell contraction; other hormones may act via local ANG II synthesis.
    • These hormonal regulatory pathways are crucial in the pathophysiology of altered glomerular function in renal injuries.