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Pions, Vancouver.

G B Goodman, B G Douglas, S M Jackson

    International Journal of Radiation Oncology, Biology, Physics
    |December 1, 1982
    PubMed
    Summary
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    Clinical trials using pions demonstrated their effectiveness in treating malignant nodules, with no observed dissociation between acute and late skin effects. Future studies will explore Pion-Boost Therapy for brain tumors and pelvic malignancies.

    Area of Science:

    • Medical Physics
    • Radiation Oncology
    • Particle Therapy

    Background:

    • Clinical treatments utilizing pions commenced in November 1979 at TRIUMF.
    • Initial studies focused on malignant subcutaneous nodules and employed pions and conventional X-rays.

    Purpose of the Study:

    • To evaluate the efficacy and side effects of pion radiotherapy compared to X-rays.
    • To determine the relative biological effectiveness (RBE) of pions for different fractionation regimens.
    • To establish the feasibility of advanced clinical applications of pion therapy.

    Main Methods:

    • Ten patients with malignant subcutaneous nodules received treatments with pions (14 lesions) and 280 kV X-rays (37 nodules).
    • Three distinct fractionation regimens were utilized for X-ray doses, covering the anticipated RBE range of pions.

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  • Patient follow-up extended up to 27 months to assess both acute and late skin reactions.

    • Main Results:

    • The relative biological effectiveness (RBE) of pions for acute skin reactions was approximately 1.5 for 10 fractions and a maximum of 1.3 for 3 fractions.
    • No significant dissociation was observed between acute and late skin effects during the follow-up period.
    • The study paved the way for future clinical trials, including Phase 1-2 studies of Pion-Boost Therapy.

    Conclusions:

    • Pion radiotherapy shows comparable efficacy to X-rays with predictable skin reactions.
    • The established RBE values provide crucial data for future treatment planning.
    • TRIUMF is upgrading its facilities to enhance pion beam currents and dose rates, enabling broader clinical applications by 1983-1984.